Worm Interactome version 8 assembles high-quality yeast two-hybrid protein protein interactions in C. elegans. It contains 3,864 known binary protein-protein interactions from three sources:

• WI-2007, a high throughput yeast two-hybrid screen done in the Vidal lab in 2007 (1,816 interactions)
• WI-2004, a high throughput yeast two-hybrid screen done in the Vidal lab in 2004, updated and reprocessed (1,735 interactions)
• A compendium of medium throughput biological processes based yeast two-hybrid screens updated and reprocessed (554 interactions)

Details of the construction of WI8 are given in Simonis et al Nat Methods 2009. All ORF IDs refer to the WS150 version of WormBase.

Click below to access the database and download interaction datasets:

• Query the PPI dataset
• Visualize the PPI network
• Show all interactions
• Download the datasets