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Please contact Michael Calderwood with questions regarding interactome projects.
Tech Support
Please contact Tong Hao with your questions or comments.
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Acknowledgments
CCSB interactome mapping and ORFeome cloning efforts are supported by federal grants from the National Human Genome Research Institute, the National Cancer Institute and the National Science Foundation, and by funding from the Dana-Farber Cancer Institute Strategic Initiative, The Ellison Foundation and the W. M. Keck Foundation.

CCSB Human Binary Interactome Download Page

Details about the protein-protein interaction datasets are provided here.


Proteome-scale maps

Dataset Description Reference
HI-I-05 Proteome-scale map of the human binary interactome network generated by systematically screening Space-I Rual et al Nature 2005 (SOM)
HI-II-14 Proteome-scale map of the human binary interactome network generated by systematically screening Space-II Rolland et al Cell 2014


Other datasets

Dataset Description Reference
Venkatesan-09 High-quality binary interactions found in four repeat screens of the Y2H-CCSB assay pipeline Venkatesan et al Nat Methods 2009 (SOM)
Yu-11 High-quality binary interactions identified during the development of the Stitch-seq protocol Yu et al Nat Methods 2011 (SOM)


Non-systematic literature binary map

Dataset Description Reference
Lit-BM-13 High-quality recurated literature binary interactions extracted from 7 public repository in 2013 Rolland et al Cell 2014


Edgotyping

Dataset Description Reference
Edgotyping data Interaction profiles (positive and negative interactions) of disease and non-disease alleles Sahni et al Cell 2015


Isoform

Dataset Description Reference
Isoform interactions Interaction profiles (positive and negative interactions) of reference and alternative isoforms Yang et al Cell 2016


Please note that all gene identifiers (Entrez Gene IDs and HGNC Gene Symbols) are according to the initial publications.

Access to preliminary data here